CAS号：

5053-08-7

分子式：

C15H21ClN2O2

分子量：

296.79200

中文名称：

盐酸芬司必利

英文名称：

中文别名：

盐酸芬司必利;盐酸氧烯洛尔;2-噁唑烷酮-5-螺-4-[n-(2-苯基乙基)哌啶]盐酸盐;盐酸芬司匹利

英文别名：

8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one,hydrochloride;
Fenspiride (Hydrochloride);
Fenspiride HCl;
NDR-5998A;
Depiride;
Fluiden;
Pneumorel;
Tegencia hydrochloride;
Viarespan hydrochloride;
Espiran;
8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride

精确分子量/精确质量：

296.12900

极性分子表面积/PSA：

41.57000

油水分配系数/LogP：

2.87220
LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。

InChI：

InChI=1/C15H20N2O2.ClH/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13;/h1-5H,6-12H2,(H,16,18);1H

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CHEMICAL IDENTIFICATION

RTECS NUMBER :RO0375000

CHEMICAL NAME :1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-phenethyl-, monohydrochloride

CAS REGISTRY NUMBER :5053-08-7

LAST UPDATED :199012

DATA ITEMS CITED :8

MOLECULAR FORMULA :C15-H20-N2-O2.Cl-H

MOLECULAR WEIGHT :296.83

WISWESSER LINE NOTATION :T6N CXTJ A2R& C-& DT5MVOX EHJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :437 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1263,1969

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intravenous

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :122 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 193,111,1971

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :250 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 193,111,1971

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :230 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1263,1969

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intravenous

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :106 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1263,1969

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intravenous

SPECIES OBSERVED :Mammal - dog

DOSE/DURATION :74 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - aggression

REFERENCE :BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 117,343,1978

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - guinea pig

DOSE/DURATION :260 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 193,111,1971

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - guinea pig

DOSE/DURATION :210 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 193,111,1971

• 消光粉
• 流平剂
• 增稠剂
• 硅油
• 环氧树脂
• 光引发剂
• 丙烯酸树脂
• 紫外线吸收剂
• 钛白粉
• 增韧剂
• 增塑剂
• 醇胺类
• 三菱碳黑
• 抗静电剂
• 丙烯酸单体
• 附着力促进剂
• 抗氧剂
• 偶联剂
• 阻燃剂
• 醇醚类
• 纤维素酯
• 表面活性剂
• 水处理树脂
• 异氰酸酯固化剂
• 消泡剂
• 润湿剂
• 润滑剂
• 纤维素醚
• 有机颜料
• 蜡粉蜡乳液
• 多功能助剂
• 聚乙烯醇PVA
• 分散剂
• 高岭土
• 群青
• 氯醋树脂
• 无机颜料