比沙可啶_Bisacodyl

比沙可啶 | CAS603-50-9

比沙可啶基本信息
CAS号	603-50-9	分子式	C22H19NO4
分子量	361.39100	精确质量	361.13100
PSA	65.49000	LogP	4.11240

基础参数

用途

MSDS

基础参数

CAS号：: 603-50-9
分子式：: C22H19NO4
分子量：: 361.39100
中文名称：: 比沙可啶
英文名称：
中文别名：: 比沙可啶;盐酸普鲁卡因;双醋苯啶;4,4'-(2-吡啶亚甲基)双酚二乙酸酯
英文别名：: Bisacodyl;
Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester) (9CI);
Phenol, 4,4'-(2-pyridylmethylene)di-, diacetate (6CI,7CI);
Phenol, 4,4'-(2-pyridylmethylene)di-, diacetate (ester) (8CI);
4,4'-(2-Pyridylmethylene)diphenol diacetate;
Alophen;
Bicol;
Bis(p-acetoxyphenyl)-2-pyridylmethane;
Brocalax;
Broxalax;
Contralax;
Correctol Caplets;
Correctol Tablets;
DAMP;
Dulcolan;
Dulcolax;
Durolax;
Endokolat;
Eulaxan;
Feen-a-Mint Tablets;
Fenilaxan;
Fleet;
Godalax;
Hillcolax;
Ivilax;
LA96a;
Laco;
Laxadin;
Laxanin N;
Laxans;
Laxine;
Laxorex;
NSC 614826;
Neolax;
Nigalax;
Perilax;
Prepacol;
Pyrilax;
SK-Bisacodyl;
Sanvacual;
Stadalax;
Telemin;
Theralax;
Ulcol;
Videx;
Zetrax
精确分子量/精确质量：: 361.13100
极性分子表面积/PSA：: 65.49000
油水分配系数/LogP：: 4.11240
LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
InChI：: InChI=1/C22H19NO4/c1-15(24)26-19-10-6-17(7-11-19)22(21-5-3-4-14-23-21)18-8-12-20(13-9-18)27-16(2)25/h3-14,22H,1-2H3

物化性质

外观与性状：白色至灰白色结晶粉末

密度：1.2 g/cm3

熔点：131 - 135ºC

沸点：492ºC

合成方法

制备方法

用于急、慢性便秘。栓剂直肠用药可用于肠镜检查、肠道X线检查或腹部手术前清洁肠道。

毒理学数据

CHEMICAL IDENTIFICATION

RTECS NUMBER :SM8750000

CHEMICAL NAME :Phenol, 4,4'-(2-pyridylmethylene)di-, diacetate (ester)

CAS REGISTRY NUMBER :603-50-9

BEILSTEIN REFERENCE NO. :0323727

LAST UPDATED :199701

DATA ITEMS CITED :11

MOLECULAR FORMULA :C22-H19-N-O4

MOLECULAR WEIGHT :361.42

WISWESSER LINE NOTATION :T6NJ BYR DOV1&R DOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :4320 mg/kg

TOXIC EFFECTS :Behavioral - altered sleep time (including change in righting reflex) Gastrointestinal - other changes Blood - changes in spleen

REFERENCE :TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,243,1960

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :17500 mg/kg

TOXIC EFFECTS :Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation Blood - hemorrhage

REFERENCE :TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,243,1960

TYPE OF TEST :LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :Intravenous

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :80 mg/kg