CAS号：

136-47-0

分子式：

C15H25ClN2O2

分子量：

300.82400

中文名称：

盐酸丁卡因

英文名称：

中文别名：

盐酸丁卡因;潘托卡因;丁卡因盐酸盐;4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯盐酸盐;對卡因

英文别名：

Tetracaine hydrochloride;
decicaine;
anethaine;
4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Ameth;
Tetracaine (hydrochloride);
decicain;
Tetracaine HCl;
PANTOCAINE;
4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Amethocaine hydrochloride;
butethanol;
menonasal;
anacel;
curtacain;
tonexol;
gingicainm

精确分子量/精确质量：

300.16000

极性分子表面积/PSA：

41.57000

油水分配系数/LogP：

3.49200
LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。

InChI：

InChI=1/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H

外观与性状：白色或灰白色结晶粉末

熔点：149°C

沸点：389.4ºC at 760 mmHg

闪点：189.3ºC

蒸汽压：2.87E-06mmHg at 25°C

制备方法

1、局部麻醉药。2、局麻作用比普鲁卡因强，毒性亦较大，能透过粘膜，主要用于粘膜麻醉。

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CHEMICAL IDENTIFICATION

RTECS NUMBER :DG4900000

CHEMICAL NAME :Benzoic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester, monohydrochloride

CAS REGISTRY NUMBER :136-47-0

LAST UPDATED :199806

DATA ITEMS CITED :18

MOLECULAR FORMULA :C15-H24-N2-O2.Cl-H

MOLECULAR WEIGHT :300.87

WISWESSER LINE NOTATION :4MR DVO2N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :Standard Draize test

ROUTE OF EXPOSURE :Administration into the eye

SPECIES OBSERVED :Rodent - rabbit

REFERENCE :ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,181,1958 ** ACUTE TOXICITY DATA **

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :23500 ug/kg

TOXIC EFFECTS :Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,413,1975

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Subcutaneous

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :24 mg/kg

TOXIC EFFECTS :Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,413,1975

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intravenous

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :4500 ug/kg

TOXIC EFFECTS :Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,413,1975

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :160 mg/kg

TOXIC EFFECTS :Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

REFERENCE :OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,413,1975

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :23 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 321,115,1988

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Subcutaneous

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :25 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 22,138,1959

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intravenous

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :6400 ug/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,815,1995

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Subcutaneous

SPECIES OBSERVED :Rodent - rabbit

DOSE/DURATION :15 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,388,1948

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intravenous

SPECIES OBSERVED :Rodent - rabbit

DOSE/DURATION :2150 ug/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,490,1982

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intratracheal

SPECIES OBSERVED :Rodent - rabbit

DOSE/DURATION :4400 ug/kg

TOXIC EFFECTS :Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

REFERENCE :JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 132,87,1961

TYPE OF TEST :LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :Intraspinal

SPECIES OBSERVED :Rodent - rabbit

DOSE/DURATION :5 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 57,221,1936

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Subcutaneous

SPECIES OBSERVED :Rodent - guinea pig

DOSE/DURATION :19500 ug/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 20,380,1947

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intravenous

SPECIES OBSERVED :Rodent - guinea pig

DOSE/DURATION :4 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,739,1957 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81540 No. of Facilities: 528 (estimated) No. of Industries: 6 No. of Occupations: 5 No. of Employees: 14149 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81540 No. of Facilities: 1008 (estimated) No. of Industries: 3 No. of Occupations: 16 No. of Employees: 67099 (estimated) No. of Female Employees: 55783 (estimated)

• 消光粉
• 流平剂
• 增稠剂
• 硅油
• 环氧树脂
• 光引发剂
• 丙烯酸树脂
• 紫外线吸收剂
• 钛白粉
• 增韧剂
• 增塑剂
• 醇胺类
• 三菱碳黑
• 抗静电剂
• 丙烯酸单体
• 附着力促进剂
• 抗氧剂
• 偶联剂
• 阻燃剂
• 醇醚类
• 纤维素酯
• 表面活性剂
• 水处理树脂
• 异氰酸酯固化剂
• 消泡剂
• 润湿剂
• 润滑剂
• 纤维素醚
• 有机颜料
• 蜡粉蜡乳液
• 多功能助剂
• 聚乙烯醇PVA
• 分散剂
• 高岭土
• 群青
• 氯醋树脂
• 无机颜料

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:2

3.氢键受体数量:4

4.可旋转化学键数量:9

5.互变异构体数量:3

6.拓扑分子极性表面积41.6

7.重原子数量:20

8.表面电荷:0

9.复杂度:249

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:2