CAS号：

36322-90-4

分子式：

C15H13N3O4S

分子量：

331.34600

中文名称：

吡罗昔康

英文名称：

中文别名：

吡罗昔康;炎痛喜康;吡啶苯噻酰胺;吡氧噻嗪;2-甲基-4-羟基-N-(2-吡啶基)-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物

英文别名：

piroxicam;
Erazon;
Larapam;
4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide;
4-Hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-2H-1,2-benzothiazine 1,1-Dioxide;
4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide;
chf1251;
Feldene;
4-Hydroxy-2-methyl-N-(pyridin-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide;
Baxo;
Pirkam;
Geldene;
1,2-benzothiazine-3-carboxamide;
Piroxicam;
Zunden;
Riacen

精确分子量/精确质量：

331.06300

极性分子表面积/PSA：

107.98000

油水分配系数/LogP：

2.67270
LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。

InChI：

InChI=1/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)

外观与性状：灰白色至淡黄色固体

密度：1.563 g/cm3

熔点：198-200°C

折射率：1.714

制备方法

非甾体抗炎药，用于类风湿性和风湿性关节炎，缓解各种关节炎及软组织病变的疼痛和肿胀的对症治疗。

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CHEMICAL IDENTIFICATION

RTECS NUMBER :DL0705000

CHEMICAL NAME :2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide

CAS REGISTRY NUMBER :36322-90-4

LAST UPDATED :199801

DATA ITEMS CITED :29

MOLECULAR FORMULA :C15-H13-N3-O4-S

MOLECULAR WEIGHT :331.37

WISWESSER LINE NOTATION :T66 BSWNJ C1 EQ DVM- BT6NJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Human - man

DOSE/DURATION :7636 mg/kg/6W-I

TOXIC EFFECTS :Kidney, Ureter, Bladder - interstitial nephritis

REFERENCE :AJNED9 American Journal of Nephrology. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 5,142,1985

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Human - child

DOSE/DURATION :7143 ug/kg

TOXIC EFFECTS :Behavioral - convulsions or effect on seizure threshold Blood - aplastic anemia Nutritional and Gross Metabolic - other changes

REFERENCE :SAMJAF South African Medical Journal. (Medical Assoc. of South Africa, Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932- Volume(issue)/page/year: 66,31,1984

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Human - man

DOSE/DURATION :52 mg/kg/26W-I

TOXIC EFFECTS :Nutritional and Gross Metabolic - metabolic acidosis

REFERENCE :AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 99,282,1983

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Human - woman

DOSE/DURATION :1200 ug/kg/3D-I

TOXIC EFFECTS :Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont., Canada) V.1- 1974- Volume(issue)/page/year: 11,554,1984

TYPE OF TEST :LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Human - man

DOSE/DURATION :3714 mg/kg/13D-I

TOXIC EFFECTS :Blood - agranulocytosis Skin and Appendages - dermatitis, allergic (after systemic exposure)

REFERENCE :NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 309,795,1983

TYPE OF TEST :LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Human - woman

DOSE/DURATION :2400 ug/kg

TOXIC EFFECTS :Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring) Liver - jaundice, other or unclassified Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 293,540,1986

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Human - woman

DOSE/DURATION :28 mg/kg

TOXIC EFFECTS :Behavioral - headache Gastrointestinal - ulceration or bleeding from duodenum Gastrointestinal - nausea or vomiting

REFERENCE :AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year: 216,335,1984

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :216 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1714,1978

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Administration onto the skin

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :>5 gm/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 37(11),-,1986

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :335 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4639,1980

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Subcutaneous

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :148 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4639,1980

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Rectal

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :400 mg/kg

TOXIC EFFECTS :Behavioral - analgesia Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,87,1981

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :250 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0079639

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :290 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 49,98,1986

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Subcutaneous

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :300 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4639,1980

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Mammal - dog

DOSE/DURATION :108 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4639,1980

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Primate - monkey

DOSE/DURATION :1 gm/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4639,1980

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - guinea pig

DOSE/DURATION :388 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 7,365,1984

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - hamster

DOSE/DURATION :170 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 7,365,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :600 mg/kg/30D-I

TOXIC EFFECTS :Gastrointestinal - ulceration or bleeding from small intestine Blood - normocytic anemia

REFERENCE :YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 35(1),-,1984

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :1825 mg/kg/1Y-I

TOXIC EFFECTS :Gastrointestinal - ulceration or bleeding from stomach Kidney, Ureter, Bladder - other changes Blood - normocytic anemia

REFERENCE :YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 35(1),-,1984 ** REPRODUCTIVE DATA **

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :35 mg/kg

SEX/DURATION :female 15-21 day(s) after conception

TOXIC EFFECTS :Reproductive - Maternal Effects - parturition

REFERENCE :TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 30,59,1984

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :110 mg/kg

SEX/DURATION :female 7-17 day(s) after conception

TOXIC EFFECTS :Reproductive - Maternal Effects - parturition Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4655,1980

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :110 mg/kg

SEX/DURATION :female 7-17 day(s) after conception

TOXIC EFFECTS :Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4655,1980

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :110 mg/kg

SEX/DURATION :female 7-17 day(s) after conception

TOXIC EFFECTS :Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4655,1980

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :55 mg/kg

SEX/DURATION :female 7-17 day(s) after conception

TOXIC EFFECTS :Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4655,1980

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :34 mg/kg

SEX/DURATION :female 1-17 day(s) after conception

TOXIC EFFECTS :Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 30,59,1984

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :260 mg/kg

SEX/DURATION :female 6-18 day(s) after conception

TOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4655,1980

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :910 mg/kg

SEX/DURATION :female 6-18 day(s) after conception

TOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 8,4655,1980

• 消光粉
• 流平剂
• 增稠剂
• 硅油
• 环氧树脂
• 光引发剂
• 丙烯酸树脂
• 紫外线吸收剂
• 钛白粉
• 增韧剂
• 增塑剂
• 醇胺类
• 三菱碳黑
• 抗静电剂
• 丙烯酸单体
• 附着力促进剂
• 抗氧剂
• 偶联剂
• 阻燃剂
• 醇醚类
• 纤维素酯
• 表面活性剂
• 水处理树脂
• 异氰酸酯固化剂
• 消泡剂
• 润湿剂
• 润滑剂
• 纤维素醚
• 有机颜料
• 蜡粉蜡乳液
• 多功能助剂
• 聚乙烯醇PVA
• 分散剂
• 高岭土
• 群青
• 氯醋树脂
• 无机颜料

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:2

3.氢键受体数量:6

4.可旋转化学键数量:2

5.互变异构体数量:8

6.拓扑分子极性表面积108

7.重原子数量:23

8.表面电荷:0

9.复杂度:611

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

安全信息

包装等级：III

风险类别：6.1(b)

海关代码：3005101000

危险类别码：R22

安全说明：S26-S36

RTECS号：DL0705000

危险标志：Xn:Harmful

海关信息

• 504-29-0

  2-氨基吡啶

• 80201-73-6

  2-methoxyethyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

• 15448-99-4

  N-甲基糖精

• 5221-37-4

  2-氯-N-吡啶-2-基乙酰胺

• 35511-15-0

  甲基物

• 99464-64-9

  安吡昔康

• 90101-16-9

  屈昔康

• 15448-99-4

  N-甲基糖精