CAS号：

62-55-5

分子式：

C2H5NS

分子量：

75.13280

中文名称：

硫代乙酰胺

英文名称：

中文别名：

硫代乙酰胺;乙硫酰胺;乙硫羰醯胺

英文别名：

thioacetamide;
USAF cb-21;
hioacetamide;
thio-acetamid;
CH3CSNH2;
Thiacetamide;
usafek-1719;
Thioactamide;
ethanethioamide;
Thioacetamide

精确分子量/精确质量：

75.01430

极性分子表面积/PSA：

58.11000

油水分配系数/LogP：

0.99270
LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。

InChI：

InChI=1/C2H5NS/c1-2(3)4/h1H3,(H2,3,4)

外观与性状：白色固体

密度：1.37

熔点：108-112 °C(lit.)

沸点：111.7ºC at 760 mmHg

闪点：21.4ºC

水溶解性：16.3 g/100 mL (25 ºC)

折射率：1.543

存储条件/存储方法：

本品应密封于阴凉干燥处保存。

稳定性相关：

其水溶液在室温或50-60℃时相当稳定，但当有氢离子存在时，很快产生硫代氢而分解。新制品有时有硫醇臭、微吸潮。

其它信息：

1. 性状：无色或白色结晶。新制品有时有硫醇臭、微吸潮。

2. 密度（g/mL,25/4℃）：1.37

3. 相对蒸汽密度（g/mL,空气=1）：不确定

4. 熔点（ºC）：108-112(lit.)

5. 沸点（ºC,常压）：不确定

6. 沸点（ºC, 5.2kPa）：不确定

7. 折射率：不确定

8. 闪点（ºC）：不确定

9. 比旋光度（º）：不确定

10. 自燃点或引燃温度（ºC）：不确定

11. 蒸气压（kPa,25ºC）：不确定

12. 饱和蒸气压（kPa,60ºC）：不确定

13. 燃烧热（KJ/mol）：不确定

14. 临界温度（ºC）：不确定

15. 临界压力（KPa）：不确定

16. 油水（辛醇/水）分配系数的对数值：不确定

17. 爆炸上限（%,V/V）：不确定

18. 爆炸下限（%,V/V）：不确定

19. 溶解性：25℃水中的溶解度16.3g/100ml，乙醇26.4g/100ml。极微溶于苯、乙醚。其水溶液在室温或50-60℃时相当稳定，但当有氢离子存在时，很快产生硫代氢而分解

制备方法

1.乙腈与硫化氢反应,或使乙酰胺与五硫化二磷反应可制得硫代乙酰胺。 2. 先将溶剂苯加热到70℃,然后加入工业品乙酰胺,搅拌至完全溶解。然后在快速搅拌下慢慢加入研碎的工业品五硫化二磷 ( 乙酰胺用量为计算量的5倍) 。反应液继续加热至由绿色变为黄色。停止搅拌,小心将黄色溶液分出并冷却结晶,静置2h,过滤,固体在空气中干燥。将滤液蒸馏,除去2/3的苯,冷却结晶,过滤后与上述所得固体合并,即为成品。所得滤液还可回收一些产物。 过程反应式为:

合成制备方法

1.乙腈与硫化氢反应，或使乙酰胺与五硫化二磷反应可制得硫代乙酰胺。

2. 先将溶剂苯加热到70℃，然后加入工业品乙酰胺，搅拌至完全溶解。然后在快速搅拌下慢慢加入研碎的工业品五硫化二磷 （ 乙酰胺用量为计算量的5倍） 。反应液继续加热至由绿色变为黄色。停止搅拌，小心将黄色溶液分出并冷却结晶，静置2h，过滤，固体在空气中干燥。将滤液蒸馏，除去2／3的苯，冷却结晶，过滤后与上述所得固体合并，即为成品。所得滤液还可回收一些产物。
过程反应式为：

• 75-05-8

  乙腈

• →

  ~90%

• 62-55-5

  硫代乙酰胺

• 60-35-5

  乙酰胺

• →

  ~84%

• 62-55-5

  硫代乙酰胺

• 71-23-8

  丙醇

• +

• 97893-05-5

  97893-05-5

• →

  ~59%

• 923-99-9

  亚磷酸三丙酯

• +

• 62-55-5

  硫代乙酰胺

• 巴斯夫BASF
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• 更多品牌

用作聚合物的硫化剂及交联剂、橡胶助剂、化学试剂、医药原料等，还用作催化剂、稳定剂、阻隔剂、电镀添加剂、照相用品、农药、染色助剂、选矿药剂、粉末涂料消光固化剂、d-生物素（维生素H）、发光产品的原料。

用途

1.用于生产催化剂、稳定剂、阻聚剂、电镀添加剂、照相药品、农药、染色助剂和选矿剂等。也用作聚合物的硫化剂、交联剂、橡胶助剂和医药原料。

2. 用于定性分析，代替硫化氢气体作分组试剂。

CAS号：62-55-5

3D弹球模型： 立即前往扯扯看

分子式：C2H5NS

分子量：75.13280

中文名称：硫代乙酰胺

英文名称：thioacetamide

中文别名：硫代乙酰胺;
乙硫酰胺;
乙硫羰醯胺

英文别名：thioacetamide;
USAF cb-21;
hioacetamide;
thio-acetamid;
CH3CSNH2;
Thiacetamide;
usafek-1719;
Thioactamide;
ethanethioamide;
Thioacetamide

精确分子量/精确质量：75.01430

极性分子表面积/PSA：58.11000

油水分配系数/LogP：
LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。

贝尔斯坦号/MDL：MFCD00008070

EINECS：200-541-4

PubChem：24889097

BRN：506006

InChI：InChI=1/C2H5NS/c1-2(3)4/h1H3,(H2,3,4)

1、 摩尔折射率：22.13

2、 摩尔体积（cm³/mol）：70.2

3、 等张比容（90.2K）：187.3

4、 表面张力（dyne/cm）：50.6

5、 极化率（10^-24cm³）：8.77

CHEMICAL IDENTIFICATION

RTECS NUMBER :AC8925000

CHEMICAL NAME :Acetamide, thio-

CAS REGISTRY NUMBER :62-55-5

LAST UPDATED :199701

DATA ITEMS CITED :69

MOLECULAR FORMULA :C2-H5-N-S

MOLECULAR WEIGHT :75.14

WISWESSER LINE NOTATION :ZY1&US

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :301 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :300 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :Subcutaneous

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :2 gm/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :933 mg/kg/10W-C

TOXIC EFFECTS :Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :240 mg/kg/4D-I

TOXIC EFFECTS :Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other hydrolases

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :1890 mg/kg/4W-C

TOXIC EFFECTS :Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :3648 mg/kg/27W-C

TOXIC EFFECTS :Liver - other changes

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :7350 mg/kg/40W-C

TOXIC EFFECTS :Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :10 gm/kg/39W-C

TOXIC EFFECTS :Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :6000 mg/kg/43W-C

TOXIC EFFECTS :Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :7200 mg/kg/51W-C

TOXIC EFFECTS :Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :1008 mg/kg/9W-C

TOXIC EFFECTS :Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :9900 mg/kg/71W-C

TOXIC EFFECTS :Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :1600 mg/kg/12W-C

TOXIC EFFECTS :Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :5140 mg/kg/47W-C

TOXIC EFFECTS :Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Reproductive - Tumorigenic effects - prostate tumors

TYPE OF TEST :TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :7665 mg/kg/1Y-C

TOXIC EFFECTS :Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :7956 mg/kg/32W-C

TOXIC EFFECTS :Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :4320 mg/kg/34W-C

TOXIC EFFECTS :Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :18360 mg/kg/73W-C

TOXIC EFFECTS :Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

DOSE :1 gm/kg

SEX/DURATION :female 7 day(s) after conception

TOXIC EFFECTS :Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Intraperitoneal

DOSE :150 mg/kg

SEX/DURATION :female 9-11 day(s) after conception

TOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - hepatobiliary system

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Subcutaneous

DOSE :1935 mg/kg

SEX/DURATION :female 6-14 day(s) after conception

TOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :Sex chromosome loss and nondisjunction

TYPE OF TEST :Sex chromosome loss and nondisjunction

TYPE OF TEST :Morphological transformation

TYPE OF TEST :DNA adduct

TYPE OF TEST :Unscheduled DNA synthesis

TYPE OF TEST :Unscheduled DNA synthesis

TYPE OF TEST :Cytogenetic analysis

TYPE OF TEST :Cytogenetic analysis

TYPE OF TEST :Micronucleus test

TYPE OF TEST :Unscheduled DNA synthesis

TYPE OF TEST :Mutation test systems - not otherwise specified

TYPE OF TEST :Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :Mutation test systems - not otherwise specified

TEST SYSTEM :Primate - monkey Kidney

DOSE/DURATION :25 mg/L/48H

REFERENCE :ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 57,193,1969 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,77,1974 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,77,1974 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 1(1),93,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83086 No. of Facilities: 47 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1130 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83086 No. of Facilities: 53 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 786 (estimated) No. of Female Employees: 592 (estimated)

• 消光粉
• 流平剂
• 增稠剂
• 硅油
• 环氧树脂
• 光引发剂
• 丙烯酸树脂
• 紫外线吸收剂
• 钛白粉
• 增韧剂
• 增塑剂
• 醇胺类
• 三菱碳黑
• 抗静电剂
• 丙烯酸单体
• 附着力促进剂
• 抗氧剂
• 偶联剂
• 阻燃剂
• 醇醚类
• 纤维素酯
• 表面活性剂
• 水处理树脂
• 异氰酸酯固化剂
• 消泡剂
• 润湿剂
• 润滑剂
• 纤维素醚
• 有机颜料
• 蜡粉蜡乳液
• 多功能助剂
• 聚乙烯醇PVA
• 分散剂
• 高岭土
• 群青
• 氯醋树脂
• 无机颜料

1.疏水参数计算参考值（XlogP）:-0.3

2.氢键供体数量:1

3.氢键受体数量:1

4.可旋转化学键数量:0

5.互变异构体数量:3

6.拓扑分子极性表面积58.1

7.重原子数量:4

8.表面电荷:0

9.复杂度:33

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

安全信息

海关代码：2942000000

WGK_Germany：3
德国有关水污染物质的分类清单

危险类别码：R22;R36/38;R45;R52/53

安全说明：S53-S45-S61

RTECS号：AC8925000

安全标志：S53:避免暴露——使用前先阅读专门的说明。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S61:避免排放到环境中。参考专门的说明/安全数据表。

危险标志：T:Toxic;

海关信息

• 60-35-5

  乙酰胺

• 75-05-8

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• 2669-09-2

  1-sulfinylethanamine

• 631-61-8

  乙酸铵

• 2825-81-2

  (E)-methyl ester,2-Hexadecenoic acid

• 2345-28-0

  2-十五烷酮

• 2825-80-1

  7顺-十六碳烯酸甲酯

• 111930-94-0

  methyl 2-methyl-4-tridecyl-4,5-dihydro-1,3-thiazole-5-carboxylate

• 1050392-22-7

  3-氨基-3-(4-甲氧基苯基)-2-甲基-2-硫代丙烯酰胺