CAS号：

23964-57-0

分子式：

C13H21ClN2O3S

分子量：

320.83500

中文名称：

盐酸阿替卡因

英文名称：

中文别名：

盐酸阿替卡因;4-甲基-3-(2-丙氨基丙酰基氨基)-2-噻吩羧酸甲酯盐酸盐

英文别名：

Articaine hydrochloride;
methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate,hydrochloride;
methyl 4-methyl-3-(2-(propylamino)propanamido)thiophene-2-carboxylate hydrochloride;
Articaine HCl

精确分子量/精确质量：

320.09600

极性分子表面积/PSA：

95.67000

油水分配系数/LogP：

3.43560
LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。

InChI：

InChI=1/C13H20N2O3S.ClH/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4;/h7,9,14H,5-6H2,1-4H3,(H,15,16);1H

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CHEMICAL IDENTIFICATION

RTECS NUMBER :XM8511000

CHEMICAL NAME :2-Thiophenecarboxylic acid, 4-methyl-3-(2-(propylamino)propionamido)-, methyl ester, monohydrochloride

CAS REGISTRY NUMBER :23964-57-0

LAST UPDATED :198412

DATA ITEMS CITED :1

MOLECULAR FORMULA :C13-H20-N2-O3-S.Cl-H

MOLECULAR WEIGHT :320.87

WISWESSER LINE NOTATION :T5SJ BVO1 CMVY1&M3 D1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intravenous

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :37 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

REFERENCE :PAWIAT Praktische Anaesthesie, Wiederbelegung und Intensivtherapie. (Stuttgart, Fed. Rep. Ger.) V.9-14, 1974-79. Volume(issue)/page/year: 9,135,1974

• 消光粉
• 流平剂
• 增稠剂
• 硅油
• 环氧树脂
• 光引发剂
• 丙烯酸树脂
• 紫外线吸收剂
• 钛白粉
• 增韧剂
• 增塑剂
• 醇胺类
• 三菱碳黑
• 抗静电剂
• 丙烯酸单体
• 附着力促进剂
• 抗氧剂
• 偶联剂
• 阻燃剂
• 醇醚类
• 纤维素酯
• 表面活性剂
• 水处理树脂
• 异氰酸酯固化剂
• 消泡剂
• 润湿剂
• 润滑剂
• 纤维素醚
• 有机颜料
• 蜡粉蜡乳液
• 多功能助剂
• 聚乙烯醇PVA
• 分散剂
• 高岭土
• 群青
• 氯醋树脂
• 无机颜料

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifiers

Product name: Articaine hydrochloride

REACH No.: A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not

require a registration or the registration is envisaged for a later

registration deadline.

CAS-No.: 23964-57-0

Relevant identified uses of the substance or mixture and uses advised against

Identified uses: Laboratory chemicals, Manufacture of substances

SECTION 2: Hazards identification

Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008

Skin irritation (Category 2), H315

Eye irritation (Category 2), H319

Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335

For the full text of the H-Statements mentioned in this Section, see Section 16.

Classification according to EU Directives 67/548/EEC or 1999/45/EC

Xi IrritantR36/37/38

For the full text of the R-phrases mentioned in this Section, see Section 16.

Label elements

Labelling according Regulation (EC) No 1272/2008

Pictogram

Signal wordWarning

Hazard statement(s)

H315Causes skin irritation.

H319Causes serious eye irritation.

H335May cause respiratory irritation.

Precautionary statement(s)

P261Avoid breathing dust.

P305 + P351 + P338IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing.

Supplemental Hazardnone

Statements

Other hazards - none

SECTION 3: Composition/information on ingredients

Substances

Synonyms: Carticaine chlorhydrate

Carticaine hydrochloride

4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic

acid methyl ester hydrochloride

Formula: C13H20N2O3S . HCl

Molecular Weight: 320,84 g/mol

CAS-No.: 23964-57-0

EC-No.: 245-957-7

Hazardous ingredients according to Regulation (EC) No 1272/2008

ComponentClassificationConcentration

methyl 4-methyl-3-[[(1-oxo-2-(propylamino)propyl]amino]-2-thenoate monohydrochloride

CAS-No.23964-57-0Skin Irrit. 2; Eye Irrit. 2; STOT <= 100 %

EC-No.245-957-7SE 3; H315, H319, H335

Hazardous ingredients according to Directive 1999/45/EC

ComponentClassificationConcentration

methyl 4-methyl-3-[[(1-oxo-2-(propylamino)propyl]amino]-2-thenoate monohydrochloride

CAS-No.23964-57-0Xi, R36/37/38<= 100 %

EC-No.245-957-7

For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures

Description of first aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in

section 11

Indication of any immediate medical attention and special treatment needed

no data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

no data available

Advice for firefighters

Wear self contained breathing apparatus for fire fighting if necessary.

Further information

no data available

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure

adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

For personal protection see section 8.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed

containers for disposal.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols.

Provide appropriate exhaust ventilation at places where dust is formed.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Recommended storage temperature: 2 - 8 °C

Store with desiccant.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

Control parameters

Components with workplace control parameters

Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and

at the end of workday.

Personal protective equipment

Eye/face protection

Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested

and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique

(without touching glove's outer surface) to avoid skin contact with this product. Dispose of

contaminated gloves after use in accordance with applicable laws and good laboratory practices.

Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and

the standard EN 374 derived from it.

Body 手感助剂ion

impervious clothing, The type of protective equipment must be selected according to the

concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher

level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.

Use respirators and components tested and approved under appropriate government standards

such as NIOSH (US) or CEN (EU).

Control of environmental exposure

Do not let product enter drains.

SECTION 9: Physical and chemical properties

Information on basic physical and chemical properties

a) AppearanceForm: solid

b) Odourno data available

c) Odour Thresholdno data available

d) pHno data available

e) Melting point/freezingno data available

point

f) Initial boiling point and no data available

boiling range

g) Flash pointno data available

h) Evapouration rateno data available

i) Flammability (solid, gas) no data available

j) Upper/lowerno data available

flammability or

explosive limits

k) Vapour pressureno data available

l) Vapour densityno data available

m) Relative densityno data available

n) Water solubilityno data available

o) Partition coefficient: n- no data available

octanol/water

p) Auto-ignitionno data available

temperature

q) Decompositionno data available

temperature

r) Viscosityno data available

s) Explosive propertiesno data available

t) Oxidizing propertiesno data available

Other safety information

no data available

SECTION 10: Stability and reactivity

Reactivity

no data available

Chemical stability

Stable under recommended storage conditions.

Possibility of hazardous reactions

no data available

Conditions to avoid

no data available

Incompatible materials

Strong oxidizing agents

Hazardous decomposition products

Other decomposition products - no data available

Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx),

Sulphur oxides, Hydrogen chloride gas

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

no data available

Skin corrosion/irritation

no data available

Serious eye damage/eye irritation

no data available

Respiratory or skin sensitisation

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

IARC:No component of this product present at levels greater than or equal to 0.1% is identified as

probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

no data available

Specific target organ toxicity - single exposure

no data available

Specific target organ toxicity - repeated exposure

no data available

Aspiration hazard

no data available

Additional Information

RTECS: Not available

To the best of our knowledge, the chemical, physical, and toxicological properties have not been

thoroughly investigated.

SECTION 12: Ecological information

Toxicity

no data available

Persistence and degradability

no data available

Bioaccumulative potential

no data available

Mobility in soil

no data available

Results of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

Other adverse effects

no data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material

with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.

Contaminated packaging

Dispose of as unused product.

SECTION 14: Transport information

UN number

ADR/RID: -IMDG: -IATA: -

UN proper shipping name

ADR/RID: Not dangerous goods

IMDG: Not dangerous goods

IATA:Not dangerous goods

Transport hazard class(es)

ADR/RID: -IMDG: -IATA: -

Packaging group

ADR/RID: -IMDG: -IATA: -

Environmental hazards

ADR/RID: noIMDG Marine pollutant: noIATA: no

Special precautions for user

no data available

SECTION 15: Regulatory information

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Safety, health and environmental regulations/legislation specific for the substance or mixture

no data available

Chemical Safety Assessment

For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

Eye Irrit.Eye irritation

H315Causes skin irritation.

H319Causes serious eye irritation.

H335May cause respiratory irritation.

Skin Irrit.Skin irritation

STOT SESpecific target organ toxicity - single exposure

Full text of R-phrases referred to under sections 2 and 3

XiIrritant

R36/37/38Irritating to eyes, respiratory system and skin.

Further information

Copyright 2014 Co. LLC. License granted to make unlimited paper copies for internal use

only.

The above information is believed to be correct but does not purport to be all inclusive and shall be

used only as a guide. The information in this document is based on the present state of our knowledge

and is applicable to the product with regard to appropriate safety precautions. It does not represent any

guarantee of the properties of the product. Corporation and its Affiliates shall not be held

liable for any damage resulting from handling or from contact with the above product. See

and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.